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Unfractionated heparin is a mixture of glycosaminoglycans that works by binding to antithrombin to inactivate thrombin (factor IIa) and factor Xa.

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Some specific classes of medications to avoid while taking anticoagulants are antifungals (such as Ketoconazole) and NSAIDs (such as Ibuprofen and Naproxen), which may put patients at an increased risk of bleeding.

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